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reasoning benchmark

GeneBench-Pro Leaderboard

GeneBench-Pro is a research-level benchmark of 129 multi-stage computational-biology problems spanning genomics, quantitative biology, and translational biomedicine.

Updated Sep 5, 2026

Models4
Model coverage4
MetricScore
EvidenceB

On this page

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  • FAQ

GeneBench-Pro Ranking

Higher score ranks better on this benchmark.

4 rows
Columns

Show columns

Sort by
Rank
Model
Score
Percentile
Participants
Evidence
Evaluated
Rank01ModelOPGPT-6 AstraOpenAIScore37.80%Percentile100.00%Participants4EvidenceCEvaluatedSep 8, 2026
Rank02ModelOPGPT-5.6 SolOpenAIScore28.70%Percentile66.67%Participants4EvidenceCEvaluatedSep 8, 2026
Rank03ModelOPGPT-5.6 TerraOpenAIScore23.30%Percentile33.33%Participants4EvidenceCEvaluatedSep 8, 2026
Rank04ModelOPGPT-5.6 LunaOpenAIScore10.80%Percentile0.00%Participants4EvidenceCEvaluatedSep 8, 2026

GeneBench-Pro Highlights

The leading models and scores on this benchmark.

GeneBench-Pro Score Distribution

A closer view of the leading scores on this benchmark.

GeneBench-Pro

The Top AI Models for GeneBench-Pro

The first five results on this benchmark, with official price and output speed added where the model identity can be matched.

What is GeneBench-Pro?

What GeneBench-Pro measures and how its scores work.

GeneBench-Pro presents agents with messy datasets, brief context, and a target estimand, requiring dependent inferential decision points to reach a verifiable answer.

It measures performance on these problems using Score, reported as a ratio.

Scores are shown in ratio. This benchmark is not independently verified and has an evidence level of B.

Family
GeneBench-Pro
Modality
text
Primary category
reasoning
Score direction
higher
LLMBoard eligible
No
Evaluation key
overall

LLM Stats. Benchmark scores retain their original unit. Overall score eligibility is shown separately.

FAQ

Common questions about GeneBench-Pro.

Which model scores highest on GeneBench-Pro?

GPT-6 Astra is currently ranked first with 37.80%.

What are the top three models on GeneBench-Pro?

The current leaders are GPT-6 Astra (37.80%), GPT-5.6 Sol (28.70%), and GPT-5.6 Terra (23.30%).

Which GeneBench-Pro model has the lowest official input price?

GPT-5.6 Luna has the lowest matched official input price at $0.20 input / $1.2 output per 1M tokens.

Which models are fastest among GeneBench-Pro results?

The fastest matched records are GPT-5.6 Terra (99.35 tok/s via OpenAI), GPT-5.6 Luna (41.87 tok/s via OpenAI), and GPT-6 Astra (30.66 tok/s via OpenAI).

Does the highest score result prove overall model quality?

No. This benchmark measures one defined capability or task. The overall LLMBoard score uses a separate aggregation across eligible benchmark evidence.

What does GeneBench-Pro measure?

It measures performance on these problems using Score, reported as a ratio.

Is a higher score better?

Yes. Higher values rank better for this benchmark.

How many models are compared?

4 model results are currently shown.

Does this benchmark affect the overall score?

No. This benchmark is shown for reference but does not contribute to the overall score.

Rank #1GPT-6 Astra37.80%
Rank #2GPT-5.6 Sol28.70%
Rank #3GPT-5.6 Terra23.30%
Rank #4GPT-5.6 Luna10.80%

Ranking basisThis genebench-pro AI model leaderboard uses descending score in the benchmark original unit. The leaderboard ranking keeps matched price and speed data separate from benchmark evidence.

  1. 01
    OP
    GPT-6 AstraOpenAI
    Score
    37.80%
    Price
    $10 input / $50 output per 1M tokens
    Speed
    Up to 30.66 tok/s via OpenAI

    Strengths

    • Ranks #1 of 4 compared models
    • 100th percentile on this benchmark
    • C evidence result

    Considerations

    • This result measures GeneBench-Pro, not total model capability
  2. 02
    OP
    GPT-5.6 SolOpenAI
    Score
    28.70%
    Price
    $4.0 input / $20 output per 1M tokens
    Speed
    Up to 2.36 tok/s via OpenAI

    Strengths

    • Ranks #2 of 4 compared models
    • 67th percentile on this benchmark
    • C evidence result

    Considerations

    • This result measures GeneBench-Pro, not total model capability
  3. 03
    OP
    OpenAI
    Score
    23.30%
    Price
    $2.0 input / $12 output per 1M tokens
    Speed
    Up to 99.35 tok/s via OpenAI

    Strengths

    • Ranks #3 of 4 compared models
    • 33th percentile on this benchmark
    • C evidence result

    Considerations

    • This result measures GeneBench-Pro, not total model capability
  4. 04
    OP
    OpenAI
    Score
    10.80%
    Price
    $0.20 input / $1.2 output per 1M tokens
    Speed
    Up to 41.87 tok/s via OpenAI

    Strengths

    • Ranks #4 of 4 compared models
    • 0th percentile on this benchmark
    • C evidence result

    Considerations

    • This result measures GeneBench-Pro, not total model capability

Selection summary

Best AI Models for GeneBench-Pro

GPT-6 Astra currently leads GeneBench-Pro with 37.80%. It is the top model on this specific benchmark, while the best LLM for the broader task should also be checked against other benchmarks, price, and runtime.

Use this leaderboard with the supporting benchmark results and coverage details above. A leaderboard position summarizes the selected ranking signal; it does not replace workload-specific testing.

GPT-5.6 Terra
GPT-5.6 Luna
Benchmark rank #1GPT-6 Astra37.80% · $10 input / $50 output per 1M tokens
Benchmark rank #2GPT-5.6 Sol28.70% · $4.0 input / $20 output per 1M tokens
Benchmark rank #3GPT-5.6 Terra23.30% · $2.0 input / $12 output per 1M tokens