science benchmark
De novo protein binder design Leaderboard
De novo protein binder design requires designing a set of 30 miniprotein binders for each of 15 protein targets within a fixed 24-hour wall-clock budget, given the target structure.
Updated Oct 23, 2026
Models1
Model coverage1
MetricScore
EvidenceB
De novo protein binder design Ranking
Higher score ranks better on this benchmark.
Sort by
Rank | Model | Score | Percentile | Participants | Evidence | Evaluated |
|---|
| Rank01 | ModelAN | Score82.30% | Percentile100.00% | Participants1 | EvidenceC | Evaluated |
De novo protein binder design Highlights
The leading models and scores on this benchmark.
The Top AI Models for De novo protein binder design
The first five results on this benchmark, with official price and output speed added where the model identity can be matched.
Ranking basisThis de novo protein binder design AI model leaderboard uses descending score in the benchmark original unit. The leaderboard ranking keeps matched price and speed data separate from benchmark evidence.
- 01ANAnthropic
- Score
- 82.30%
- Price
- $2.0 input / $10 output per 1M tokens
- Speed
- Up to 42.00 tok/s via Anthropic
Strengths
- Ranks #1 of 1 compared models
- 100th percentile on this benchmark
- C evidence result
Considerations
- This result measures De novo protein binder design, not total model capability
Selection summary
Best AI Models for De novo protein binder design
Claude Sonnet 5.5 currently leads De novo protein binder design with 82.30%. It is the top model on this specific benchmark, while the best LLM for the broader task should also be checked against other benchmarks, price, and runtime.
Use this leaderboard with the supporting benchmark results and coverage details above. A leaderboard position summarizes the selected ranking signal; it does not replace workload-specific testing.
What is De novo protein binder design?
What De novo protein binder design measures and how its scores work.
A science benchmark for de novo protein binder design across 15 protein targets.
It reports a Score in ratio units for designing 30 miniprotein binders per target within the fixed 24-hour wall-clock budget.
Scores are shown in ratio. This benchmark is not independently verified and has an evidence level of B.
- Family
- De novo protein binder design
- Modality
- text
- Primary category
- science
- Score direction
- higher
- LLMBoard eligible
- No
- Evaluation key
- overall
LLM Stats. Benchmark scores retain their original unit. Overall score eligibility is shown separately.
FAQ
Common questions about De novo protein binder design.
Which model scores highest on De novo protein binder design?
Claude Sonnet 5.5 is currently ranked first with 82.30%.
What are the top three models on De novo protein binder design?
The current leaders are Claude Sonnet 5.5 (82.30%).
Which De novo protein binder design model has the lowest official input price?
Claude Sonnet 5.5 has the lowest matched official input price at $2.0 input / $10 output per 1M tokens.
Which models are fastest among De novo protein binder design results?
The fastest matched records are Claude Sonnet 5.5 (42.00 tok/s via Anthropic).
Does the highest score result prove overall model quality?
No. This benchmark measures one defined capability or task. The overall LLMBoard score uses a separate aggregation across eligible benchmark evidence.